A car laden with explosives was set off at the Iranian ambassador's residence in the Yemeni capital Sanaa on Wednesday.
The Foreign Ministry Spokesperson Marzieh Afkham condemned the incident, which killed at least three people.
Afkham told reporters, "All the Iranian staff members at the mission were unhurt," including the ambassador who had left his residence for the embassy minutes before the attack.
Reuters quoted an eyewitness at the scene of the incident as saying the attack punched a large hole in the building and sent rubble flying across the street of the well-guarded diplomatic quarter of the city.
There was no immediate claim of responsibility for the attack, but Reuters said it mirrored past bombings carried out by al Qaeda in the Arabian Peninsula (AQAP).
Iranian diplomats have been targeted in Yemen before. One diplomat is being held hostage by suspected militants and another was killed this year when he resisted a kidnapping attempt.
The deputy foreign minister also condemned the bombing and urged the Yemeni government to immediately identify the perpetrators of the incident.
"We expect Yemen's government to act immediately to punish those behind the attack and take serious measures to secure the release of the kidnapped Iranian diplomat, Nour Ahmad Nikbakht," Hossein Amir-Abdollahian said on Wednesday, IRNA reported.
