Researchers from Tehran University of Medical Sciences have produced a nanocomposite to treat damaged bone.
The nanocomposite is biocompatible and contains antibacterial nanoparticles. Laboratorial studies showed that the nanocomposite is able to prevent the growth of bacteria and help recover the damaged bone, Iran Nanotechnology Initiative Council was quoted as announcing by Mehr News Agency.
The recovery of damaged bone tissue and side effects of surgery, including infection in the damaged area, are among main concerns in orthopedic surgeries. Therefore, it is necessary to develop antibacterial composites to boost bone repair.
Two types of nanocomposites were designed in this research to treat bone damage and reduce infection. Materials used in the composites are completely nontoxic and compatible with human body.
Moreover, the nanocomposite has been made available at a reasonable price.
The nanocomposite of hydroxyapatite/chitosan containing silver and silicon nanoparticles was produced through molecular hybridization. The aim of the research was to demonstrate the effects of size, surface roughness and chemical structure of the nanocomposite on cellular toxicity and antibacterial activity of bone-making cells (osteoblast) in humans.
Results showed that the nanocomposite containing silver increases the percentage of living cells and antibacterial activity in comparison with the nanocomposite containing silicon nanoparticles. According to the researchers, the combination of silver nanoparticles with the nanocomposite prevents the quick diffusion of silver ions and limits the toxicity of the product in the cells.
As a result, silver nanocomposite is an appropriate option as filler in the treatment of broken bones due to its high potential for the recovery of bones, good compatibility and appropriate antibacterial properties.
